Mechanistic Formulation Design of Spray-Dried Powders

Spray drying is gaining traction in the pharmaceutical industry as one of processing methods choice for manufacture solid dosage forms intended pulmonary, oral, and parenteral delivery. This process particularly advantageous because its ability to produce engineered particles with improved efficacy stability by combining active ingredients or biologics appropriate excipients. Moreover, due high throughput, continuous operation, thermostable powders, spray can be a manufacturing method production drugs other formulations, including vaccines, global distribution. Formulation design based on mechanistic understanding different phenomena that occur during powders complicated therefore make use available particle formation models difficult practitioner. review aims provide step-by-step guidance accompanied critical background information successful formulation spray-dried microparticles. These include discussion tools needed estimate surface concentration each solute droplet drying, their times modes solidification, amount glass stabilizers shell formers required stable dispersible powders.